

CHO-K1/Human 5-HT4 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0009A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The 5-HT4 receptors are a type of serotonin receptors that play a key role in controlling brain functions such as learning, memory, mood, and gastrointestinal transit. They are a target for therapeutic drugs used in treating brain diseases like Alzheimer's, feeding disorders, and major depressive disorders.
Screeningbio’s CHO-K1 Human 5-HT4 cell line overexpress Human HTR4 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | 5-HT4 |
Accession Number | NM_000870 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
![CHO-K1/Human 5-HT4 Agonist Assay. CHO-K1/Human 5-HT4 cells were treated with the reference agonist 5-HT. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.](https://static.wixstatic.com/media/cbf7de_4ee0e8d41c974943b8865392be6b92f3~mv2.png/v1/fill/w_75,h_75,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/cbf7de_4ee0e8d41c974943b8865392be6b92f3~mv2.png)
Target Background
The 5-HT4 receptors are a type of serotonin receptors that play a key role in controlling brain functions such as learning, memory, mood, and gastrointestinal transit. They are a target for therapeutic drugs used in treating brain diseases like Alzheimer's, feeding disorders, and major depressive disorders.