HEK293T Human 5-HT2A β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0006A | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The 5-HT2A receptor (5-hydroxytryptamine receptor 2A) is a G protein-coupled receptor widely distributed throughout the body. It is involved in regulating various central physiological functions, such as mood, memory, sleep, nociception, feeding, and reward-related behaviors. In addition, this receptor is also believed to play a role in modulating the cardiovascular system. Studies have shown that depressed patients have a higher number of 5-HT2A receptors compared to healthy individuals, suggesting that an increase in the density of these receptors may be directly linked to the pathogenesis of the disorder.
ScreeningBio’s HEK293T/Human 5-HT2A β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | HTR2A |
Accession Number | NM_000621 (Hs) |
Parental Line | HEK293T |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The 5-HT2A receptor (5-hydroxytryptamine receptor 2A) is a G protein-coupled receptor widely distributed throughout the body. It is involved in regulating various central physiological functions, such as mood, memory, sleep, nociception, feeding, and reward-related behaviors.
In addition, this receptor is also believed to play a role in modulating the cardiovascular system. Studies have shown that depressed patients have a higher number of 5-HT2A receptors compared to healthy individuals, suggesting that an increase in the density of these receptors may be directly linked to the pathogenesis of the disorder.