top of page

CHO-K1/Rat 5-HT2C Stable Cell

Item
Cat#
Price

Stable Cell Line

SNB-G-0008C

$19,800

Compound Testing Services

CT-001

$1,850 per 384w plate

(Up To 16 cpds Dose)



Product Description


The 5-HT2C receptor is a G protein-coupled receptor (GPCR) that, upon binding to its ligand serotonin (5-HT), mediates various physiological processes in both the brain and peripheral tissues. It represents an important therapeutic target for treating obesity and other central nervous system disorders such as epilepsy, schizophrenia, and drug abuse.

 

Screeningbio’s CHO-K1/Rat 5-HT2C cell line overexpress HTR2C receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal. 

Product Specifications

Target Type

GPCR

Species

Rat

HGNC Symbol

HTR2C

Accession Number

NM_012765

Parental Line

CHO-K1

Lot#

See Vial

Storage

Liquid Nitrogen


Data

CHO-K1/Rat 5-HT2C Agonist Assay. CHO-K1/Rat 5HT2C cells were treated with the reference agonist. The assay was run based on FLIPR Calcium 6 Assay protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.
CHO-K1/Rat 5-HT2C Agonist Assay. CHO-K1/Rat 5HT2C cells were treated with the reference agonist. The assay was run based on FLIPR Calcium 6 Assay protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.


Target Background


The 5-HT2C receptor is a G protein-coupled receptor (GPCR) that, upon binding to its ligand serotonin (5-HT), mediates various physiological processes in both the brain and peripheral tissues.


It represents an important therapeutic target for treating obesity and other central nervous system disorders such as epilepsy, schizophrenia, and drug abuse.



Product Documentation



Screeningbio

For research use only. All rights reserved. Not for use in diagnostic procedures, human or veterinary treatment, food, cosmetics, or household applications. ScreeningBio provides laboratory research products and R&D services to qualified research organizations. We do not sell pharmaceuticals, dietary supplements, or products intended for human consumption.

6181 Cornerstone Ct, Suite 102, San Diego, CA 92121, USA

Quick Links

Connect

  • Facebook
  • Twitter
  • LinkedIn

CHINA: 上海格宁生物

info@screeningbio.com

4th Floor, Building 24, No.1188 Lianhang Road Minhang District, Shanghai, China

bottom of page