HEK293/Human α1B-adrenoceptor Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0023A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The α1-adrenergic receptors (α1-ARs) are members of the G protein-coupled receptor superfamily, comprising three subtypes: α1A, α1B, and α1D. Although all these subtypes signal through the Gq/11 family of proteins to mediate downstream signaling, they exhibit distinct activation patterns.α1-ARs can mediate cellular mitogenic responses and regulate the growth and proliferation of various cell types. Given their role in multiple critical physiological responses, the development of drugs targeting α1-ARs holds broad application prospects.
Screeningbio’s HEK293/Human α1B-adrenoceptor Gq cell line overexpress ADRA1B receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | α1B-adrenoceptor |
Accession Number | NM_000679 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The α1-adrenergic receptors (α1-ARs) are members of the G protein-coupled receptor superfamily, comprising three subtypes: α1A, α1B, and α1D. Although all these subtypes signal through the Gq/11 family of proteins to mediate downstream signaling, they exhibit distinct activation patterns.
α1-ARs can mediate cellular mitogenic responses and regulate the growth and proliferation of various cell types. Given their role in multiple critical physiological responses, the development of drugs targeting α1-ARs holds broad application prospects.