Product Description

The β3-adrenoceptor is a G-protein-coupled receptor primarily found on the surface of fat cells (adipocytes) and the smooth muscle of the urinary bladder. Its main roles are to stimulate the breakdown of stored fat (lipolysis) to increase energy expenditure and to promote relaxation of the bladder muscle, thereby increasing its capacity. Because of these key functions, the β3-adrenoceptor has become a significant therapeutic target, with agonists like mirabegron being successfully used to treat overactive bladder syndrome and others under investigation for their potential to combat metabolic disorders like obesity and type 2 diabetes.

Screeningbio’s CHO-K1/Rat β3-adrenoceptor cell line overexpress rat ADRB3 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.