HEK293T/Mouse OX2 β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0178B | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Orexin Receptor 2 (OXR2), also known as HCRTR2, is a G protein-coupled receptor primarily expressed in regions such as the cerebral cortex, hippocampus, and hypothalamus. OXR2 plays important physiological roles by regulating the sleep-wake cycle, mood, learning and memory, feeding behavior, reward/addiction, and energy balance. Dysfunction of OXR2 is closely associated with sleep disorders and is involved in the pathophysiology of conditions such as insomnia, hypersomnia, depression, and narcolepsy.
ScreeningBio’s HEK293T/Mouse OX2 β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | HCRTR2 |
Accession Number | NM_198962 (Mm) |
Parental Line | HEK293T |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Orexin Receptor 2 (OXR2), also known as HCRTR2, is a G protein-coupled receptor primarily expressed in regions such as the cerebral cortex, hippocampus, and hypothalamus.
OXR2 plays important physiological roles by regulating the sleep-wake cycle, mood, learning and memory, feeding behavior, reward/addiction, and energy balance. Dysfunction of OXR2 is closely associated with sleep disorders and is involved in the pathophysiology of conditions such as insomnia, hypersomnia, depression, and narcolepsy.