HEK293/Canis OX2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0178M | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Orexin Receptor 2 (OXR2), also known as HCRTR2, is a G protein-coupled receptor primarily expressed in regions such as the cerebral cortex, hippocampus, and hypothalamus. OXR2 plays important physiological roles by regulating the sleep-wake cycle, mood, learning and memory, feeding behavior, reward/addiction, and energy balance. Dysfunction of OXR2 is closely associated with sleep disorders and is involved in the pathophysiology of conditions such as insomnia, hypersomnia, depression, and narcolepsy.
Screeningbio’s HEK293/Canis OX2 cell line overexpress HCRTR2 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Canis lupus familiaris |
HGNC Symbol | HCRTR2 |
Accession Number | NM_001002933.1 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Orexin Receptor 2 (OXR2), also known as HCRTR2, is a G protein-coupled receptor primarily expressed in regions such as the cerebral cortex, hippocampus, and hypothalamus. OXR2 plays important physiological roles by regulating the sleep-wake cycle, mood, learning and memory, feeding behavior, reward/addiction, and energy balance.
Dysfunction of OXR2 is closely associated with sleep disorders and is involved in the pathophysiology of conditions such as insomnia, hypersomnia, depression, and narcolepsy.