HEK293/Human OX2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0178A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Orexin Receptor 1 (OXR1), also known as HCRTR1, is a G protein-coupled receptor (GPCR) primarily expressed in the hypothalamic region. By binding to its endogenous ligand orexin-A, it activates intracellular signaling cascades mediated by Gq proteins. Its core functions include regulating energy metabolism balance, stress responses, and the sleep-wake cycle. Dysregulation of OX1R is associated with insomnia, narcolepsy, and obesity.
Screeningbio’s HEK293/Human OX1 cell line overexpress OX1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | HCRTR2 |
Accession Number | NM_001526 (Hs) |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
![HEK293/Human OX2 Agonist Assay. HEK293/Human OX2 cells were treated with the reference agonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software.](https://static.wixstatic.com/media/cbf7de_0af250f651f94aee906d4a8bdce67602~mv2.png/v1/fill/w_75,h_75,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/cbf7de_0af250f651f94aee906d4a8bdce67602~mv2.png)
Target Background
The Orexin Receptor 2 (OXR2), also known as HCRTR2, is a G protein-coupled receptor primarily expressed in regions such as the cerebral cortex, hippocampus, and hypothalamus. OXR2 plays important physiological roles by regulating the sleep-wake cycle, mood, learning and memory, feeding behavior, reward/addiction, and energy balance.
Dysfunction of OXR2 is closely associated with sleep disorders and is involved in the pathophysiology of conditions such as insomnia, hypersomnia, depression, and narcolepsy.