CHO-K1/Cyno GIPR Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0103S | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Gastric Inhibitory Polypeptide Receptor (GIPR) is a class B G protein-coupled receptor (GPCR) that mediates the physiological actions of the incretin hormone GIP, primarily involved in glucose homeostasis and lipid metabolism. GIPR is predominantly expressed in pancreatic β-cells, adipose tissue, and the central nervous system, where it plays a key role in enhancing insulin secretion in response to nutrient intake.
Screeningbio’s CHO-K1/Cyno GIPR cell line overexpress GIPR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit xcan be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Cyno |
HGNC Symbol | GIPR |
Accession Number | XM_005589605.4 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
![CHO-K1/Cyno GIPR Antagonist Assay. CHO-K1/Cyno GIPR cells were treated with the reference antagonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.](https://static.wixstatic.com/media/cbf7de_b87edec94cee4af5bbcdd871feb1fc59~mv2.png/v1/fill/w_75,h_75,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/cbf7de_b87edec94cee4af5bbcdd871feb1fc59~mv2.png)
Target Background
The Gastric Inhibitory Polypeptide Receptor (GIPR) is a class B G protein-coupled receptor (GPCR) that mediates the physiological actions of the incretin hormone GIP, primarily involved in glucose homeostasis and lipid metabolism.
GIPR is predominantly expressed in pancreatic β-cells, adipose tissue, and the central nervous system, where it plays a key role in enhancing insulin secretion in response to nutrient intake.