CHO-K1/Mouse MC1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0142B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Melanocortin receptor 1 (MC1R) is a G protein-coupled receptor predominantly expressed in skin melanocytes and activated by melanocortins such as α-MSH. Its core function is to regulate skin and hair pigmentation: upon activation, it promotes the production of eumelanin (brown/black pigment) and inhibits pheomelanin (red/yellow pigment) synthesis via the cAMP signaling pathway, thereby determining pigment type and photoprotective capacity. Additionally, it is involved in modulating skin inflammatory responses and DNA damage repair. Loss-of-function genetic variants of MC1R are the primary factor responsible for the red hair/fair skin phenotype and the associated increased risk of UV-related skin cancers, such as melanoma.
Screeningbio’s CHO-K1/Mouse MC1 cell line overexpress MC1R and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | MC1R |
Accession Number | NM_008559 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Melanocortin receptor 1 (MC1R) is a G protein-coupled receptor predominantly expressed in skin melanocytes and activated by melanocortins such as α-MSH.
Its core function is to regulate skin and hair pigmentation: upon activation, it promotes the production of eumelanin (brown/black pigment) and inhibits pheomelanin (red/yellow pigment) synthesis via the cAMP signaling pathway, thereby determining pigment type and photoprotective capacity. Additionally, it is involved in modulating skin inflammatory responses and DNA damage repair.
Loss-of-function genetic variants of MC1R are the primary factor responsible for the red hair/fair skin phenotype and the associated increased risk of UV-related skin cancers, such as melanoma.