Product Description

The glucagon-like peptide-2 receptor (GLP-2R) is a class B G protein-coupled receptor that specifically binds the gut hormone GLP-2. It is primarily distributed throughout the intestinal tract (small and large intestine) in epithelial cells, particularly within crypt and villus regions, with minor expression in the central nervous system. Its core function is to potently stimulate intestinal mucosal epithelial cell proliferation, inhibit apoptosis, enhance gut barrier function, and improve intestinal blood flow and nutrient absorption, thereby playing a crucial role in intestinal protection, repair, and adaptation. As a key regulator of intestinal health, GLP-2R-based analogs (e.g., teduglutide) have become the standard treatment for short bowel syndrome and show therapeutic potential for conditions like Crohn's disease.

Screeningbio’s CHO-K1/Cyno GLP-2R cell line overexpress GLP-2R and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit xcan be used to detect the signal.