HEK293 Rhesus GLP-2R Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0107K | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The glucagon like peptide 2 receptor，a member of the G protein-coupled receptor (GPCR) family, is widely distributed in the gastrointestinal tract, liver, adipose tissue, and central nervous system (CNS). In the gastrointestinal tract, it is primarily expressed in intestinal epithelial cells and enteroendocrine cells, playing an essential role in maintaining normal physiological function. In the liver, it may be involved in regulating metabolism and regeneration; in adipose tissue, it may be related to lipid metabolism and energy balance; and in the central nervous system, it may contribute to neural regulation and energy homeostasis.
Screeningbio’s HEK293/Pig GLP-2R cell line overexpress GLP-2R and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rhesus |
HGNC Symbol | GLP-2R |
Accession Number | XM_001113520.4 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The glucagon-like peptide-2 receptor (GLP-2R), a member of the class B G protein-coupled receptor (GPCR) family, exhibits a wide distribution pattern across multiple organs, including the gastrointestinal tract, liver, adipose tissue, and central nervous system (CNS).
In the gastrointestinal tract, it is predominantly expressed in intestinal epithelial cells and enteroendocrine cells, where it plays an indispensable role in maintaining mucosal integrity, promoting crypt cell proliferation, and enhancing nutrient absorption. Within the liver, GLP-2R signaling may be involved in regulating hepatic lipid metabolism and facilitating liver regeneration processes. In adipose tissue, its presence suggests a potential role in modulating lipid storage, turnover, and overall energy balance.
Furthermore, GLP-2R expression in the central nervous system, particularly in regions like the hypothalamus, points to its contribution in neural circuits that govern food intake, energy homeostasis, and gut-brain axis communication.