HepG2 ARE-Luciferase Reporter Cell Line
Item | Cat# | Price |
Stable Cell Line | SNB-SP-0014 | $1,980 |
Compound Test Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The ARE (Antioxidant Response Element) signaling pathway is a core defense mechanism against oxidative stress in cells. It is primarily regulated by the transcription factor Nrf2. Under normal conditions, Nrf2 is bound to Keap1 protein and undergoes continuous degradation; when cells are stimulated by oxidative stress or electrophilic substances, Keap1 releases Nrf2. Nrf2 then translocates into the nucleus, dimerizes with Maf proteins, and binds to ARE sequences in the promoters of target genes, thereby activating the expression of a series of detoxifying enzymes and antioxidant proteins. This pathway plays a key role in maintaining cellular redox homeostasis and in chemical prevention.
Screeningbio’s HepG2/ARE/Luciferase reporter gene cell line stable transfected with ARE response element and luciferase gene. Upon stimulated, ARE pathway was activated and induce luciferase expression.
Product Specifications
Target Type | Signal Pathway |
Species | Human |
HGNC Symbol | |
Accession Number | |
Parental Line | HepG2 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The ARE (Antioxidant Response Element) signaling pathway is a core defense mechanism against oxidative stress in cells. It is primarily regulated by the transcription factor Nrf2. Under normal conditions, Nrf2 is bound to Keap1 protein and undergoes continuous degradation; when cells are stimulated by oxidative stress or electrophilic substances, Keap1 releases Nrf2.
Nrf2 then translocates into the nucleus, dimerizes with Maf proteins, and binds to ARE sequences in the promoters of target genes, thereby activating the expression of a series of detoxifying enzymes and antioxidant proteins. This pathway plays a key role in maintaining cellular redox homeostasis and in chemical prevention.