HEK293 STAT3-Luciferase Reporter Cell Line
Item | Cat# | Price |
Stable Cell Line | SNB-SP-0013 | $1,980 |
Compound Test Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The STAT3 (Signal Transducer and Activator of Transcription 3) signaling pathway plays a crucial role in transmitting signals from cytokines and growth factors to the nucleus to regulate gene expression. Activation typically begins when ligands such as IL-6 or EGF bind to their receptors, leading to activation of associated Janus kinases (JAKs) or receptor tyrosine kinases. These kinases phosphorylate STAT3 on tyrosine residues, causing its dimerization and translocation into the nucleus. Once there, STAT3 binds to specific DNA sequences to induce transcription of genes involved in cell proliferation, survival, differentiation, and immune responses. Under normal conditions, STAT3 activation is transient; however, persistent activation is frequently observed in cancers, inflammatory diseases, and fibrosis. Due to its central role in oncogenic signaling and immune regulation, the STAT3 pathway is a major target for drug development.
Screeningbio’s HEK293/STAT-3/Luciferase reporter gene cell line stable transfected with STAT-3 response element and luciferase gene. Upon stimulated, STAT-3 pathway was activated and induce luciferase expression.
Product Specifications
Target Type | Signal Pathway |
Species | Human |
HGNC Symbol | |
Accession Number | |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The STAT3 (Signal Transducer and Activator of Transcription 3) signaling pathway plays a crucial role in transmitting signals from cytokines and growth factors to the nucleus to regulate gene expression. Activation typically begins when ligands such as IL-6 or EGF bind to their receptors, leading to activation of associated Janus kinases (JAKs) or receptor tyrosine kinases. These kinases phosphorylate STAT3 on tyrosine residues, causing its dimerization and translocation into the nucleus.
Once there, STAT3 binds to specific DNA sequences to induce transcription of genes involved in cell proliferation, survival, differentiation, and immune responses. Under normal conditions, STAT3 activation is transient; however, persistent activation is frequently observed in cancers, inflammatory diseases, and fibrosis. Due to its central role in oncogenic signaling and immune regulation, the STAT3 pathway is a major target for drug development.