HEK293T/Mouse D4 β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0085B | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The dopamine D4 receptor is a member of the D2-like receptor family, notable for its high genetic polymorphism, which is linked to individual differences. It is primarily distributed in limbic system regions associated with higher cognition and emotion processing, such as the prefrontal cortex, amygdala, and hippocampus. Functionally, the D4 receptor is involved in regulating attention, cognitive flexibility, executive function, and emotional responses. Its genetic variations are a significant risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD) and are also associated with susceptibility to schizophrenia and response to atypical antipsychotic drugs, making it a key target in neuropsychiatric drug development.
ScreeningBio’s HEK293T/Mouse D4 β-Arrestin cell line co-express the SmBiT tagged Mouse D4 receptor and the LgBiT tagged β-Arrestin. Activation of the GPCR-SmBiT induces β-Arrestin-LgBiT recruitment, forcing complementation of two NanoBiT enzyme fragments (SmBiT and LgBiT). The resulting functional NanoBiT enzyme catalyze substrate to generate a luminescent signal. Promega Nano-Glo Live Cell Kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | DRD4 |
Accession Number | NM_007878 (Mm) |
Parental Line | HEK293T |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The dopamine D4 receptor is a member of the D2-like receptor family, notable for its high genetic polymorphism, which is linked to individual differences. It is primarily distributed in limbic system regions associated with higher cognition and emotion processing, such as the prefrontal cortex, amygdala, and hippocampus.
Functionally, the D4 receptor is involved in regulating attention, cognitive flexibility, executive function, and emotional responses. Its genetic variations are a significant risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD) and are also associated with susceptibility to schizophrenia and response to atypical antipsychotic drugs, making it a key target in neuropsychiatric drug development.