HEK293 Human PTH2 Stable Cell

HEK293/Human PTH2 Stable Cell

Item	Cat#	Price
Stable Cell Line	SNB-G-0189A	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

Parathyroid hormone receptor 2 (PTH2) is a G protein-coupled receptor belonging to the parathyroid hormone receptor family. It is primarily distributed in the central nervous system, such as the hypothalamus, amygdala, and spinal cord—regions associated with neuroendocrine regulation, emotion, and pain modulation—with low expression in peripheral tissues. Its endogenous ligand is tuberoinfundibular peptide of 39 residues (TIP39). The core function of the PTH2 receptor is not regulating calcium-phosphate metabolism but rather involvement in neuromodulation, including stress responses, anxiety-related behaviors, pain perception, and the regulation of neuroendocrine pathways such as oxytocin release.

Screeningbio’s HEK293/Human PTH2 cell line overexpress PTH2R and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.

Product Specifications

Target Type	GPCR
Species	Human
HGNC Symbol	PTH2R
Accession Number	SNB-G-0189A
Parental Line	HEK293
Lot#	See Vial
Storage	Liquid Nitrogen

Data

HEK293/Human PTH2 Agonist Assay. HEK293/Human PTH2 cells were treated with the reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software. — **HEK293/Human PTH2 Agonist Assay.** HEK293/Human PTH2 cells were treated with the reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.

Target Background

Parathyroid hormone receptor 2 (PTH2) is a G protein-coupled receptor belonging to the parathyroid hormone receptor family. It is primarily distributed in the central nervous system, such as the hypothalamus, amygdala, and spinal cord—regions associated with neuroendocrine regulation, emotion, and pain modulation—with low expression in peripheral tissues.

Its endogenous ligand is tuberoinfundibular peptide of 39 residues (TIP39). The core function of the PTH2 receptor is not regulating calcium-phosphate metabolism but rather involvement in neuromodulation, including stress responses, anxiety-related behaviors, pain perception, and the regulation of neuroendocrine pathways such as oxytocin release.