HEK293 Human NK2R Stable Cell

HEK293/Human NK2R Stable Cell

Item	Cat#	Price
Stable Cell Line	SNB-G-0219A	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

Tachykinin receptors are a family of G protein-coupled receptors (GPCRs) comprising three distinct subtypes: neurokinin 1 (NK1), NK2, and NK3 receptors, each exhibiting unique ligand specificity, tissue distribution, and functional roles. These receptors are activated by structurally related neuropeptides—substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)—which share a conserved C-terminal sequence (-Phe-X-Gly-Leu-Met-NH₂).

Screeningbio’s HEK293/Human NK2R cell line overexpress TACR2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.

Product Specifications

Target Type	GPCR
Species	Human
HGNC Symbol	NK2R
Accession Number	NM_001057
Parental Line	HEK293
Lot#	See Vial
Storage	Liquid Nitrogen

Data

HEK293/Human NK2R Agonist Assay. HEK293/Human NK2R cells were treated with the reference agonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software. — **HEK293/Human NK2R Agonist Assay.** HEK293/Human NK2R cells were treated with the reference agonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software.

Target Background

Tachykinin receptors are a family of G protein-coupled receptors (GPCRs) comprising three distinct subtypes: neurokinin 1 (NK1), NK2, and NK3 receptors, each exhibiting unique ligand specificity, tissue distribution, and functional roles.

These receptors are activated by structurally related neuropeptides—substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)—which share a conserved C-terminal sequence (-Phe-X-Gly-Leu-Met-NH₂).