HEK293 Human GPR133 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0282F | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
GPR133 (also known as ADGRD1) belongs to the adhesion G protein-coupled receptor (adhesion GPCR) family. Its structure allows self-cleavage at specific sites, forming two associated fragments. This property enables it to sensitively sense mechanical forces and chemical signal changes in the extracellular environment and initiate corresponding intracellular signaling. The receptor is primarily expressed in brain tissue, where it regulates intracellular cAMP levels by activating Gs protein, and participates in processes such as cell signal transduction and central nervous system development. Thus, it plays key roles in various physiological and pathological processes.
Screeningbio’s HEK293/Human GPR133 cell line overexpress GPR133 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GPR133 |
Accession Number | NM_198827.5 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
GPR133 (also known as ADGRD1) belongs to the adhesion G protein-coupled receptor (adhesion GPCR) family. Its structure allows self-cleavage at specific sites, forming two associated fragments. This property enables it to sensitively sense mechanical forces and chemical signal changes in the extracellular environment and initiate corresponding intracellular signaling.
The receptor is primarily expressed in brain tissue, where it regulates intracellular cAMP levels by activating Gs protein, and participates in processes such as cell signal transduction and central nervous system development. Thus, it plays key roles in various physiological and pathological processes.