HEK293 Human GHSR Stable Cell

HEK293/Human GHSR Stable Cell

Item	Cat#	Price
Stable Cell Line	SNB-G-0101A	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor with high affinity for ghrelin. It is primarily distributed in brain regions regulating feeding and growth, such as the hypothalamic arcuate and ventromedial nuclei, and is also found in peripheral tissues including the pituitary, pancreas, myocardium, and gastrointestinal tract. Its core function is to serve as a critical hub for ghrelin signaling, potently stimulating growth hormone secretion to regulate growth, energy balance, and appetite, while extensively participating in glucose/lipid metabolism, cardiovascular function, and stress responses. Dysregulation of GHSR is closely associated with metabolic disorders such as obesity, diabetes, and heart failure.

Screeningbio’s HEK293/Human GHSR cell line overexpress GHSR receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.

Product Specifications

Target Type	GPCR
Species	Human
HGNC Symbol	GHSR
Accession Number	NM_198407
Parental Line	HEK293
Lot#	See Vial
Storage	Liquid Nitrogen

Data

HEK293/Human GHSR Agonist Assay. HEK293/Human GHSR cells were treated with the reference agonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software. — **HEK293/Human GHSR Agonist Assay.** HEK293/Human GHSR cells were treated with the reference agonist. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software.

Target Background

The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor with high affinity for ghrelin. It is primarily distributed in brain regions regulating feeding and growth, such as the hypothalamic arcuate and ventromedial nuclei, and is also found in peripheral tissues including the pituitary, pancreas, myocardium, and gastrointestinal tract.

Its core function is to serve as a critical hub for ghrelin signaling, potently stimulating growth hormone secretion to regulate growth, energy balance, and appetite, while extensively participating in glucose/lipid metabolism, cardiovascular function, and stress responses.

Dysregulation of GHSR is closely associated with metabolic disorders such as obesity, diabetes, and heart failure.