CHO-K1/Rat V1A Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0225C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The V1A receptor (vasopressin 1A receptor) is a Gq protein-coupled receptor encoded by the AVPR1A gene, primarily distributed in vascular smooth muscle, liver, platelets, and the central nervous system (such as the hippocampus and amygdala). Its core function, upon activation by arginine vasopressin, involves mediating the phospholipase C signaling pathway via Gq protein to induce vasoconstriction, hepatic glycogenolysis, and platelet aggregation, as well as participating in the regulation of social behavior, mood, and blood pressure homeostasis. This receptor plays significant roles in conditions such as hypertension, heart failure, and social disorders, serving as a therapeutic target for clinical drugs (e.g., conivaptan).
Screeningbio’s CHO-K1/Rat V1A cell line overexpress rat AVPR1A receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | AVPR1A |
Accession Number | NM_053019 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The V1A receptor (vasopressin 1A receptor) is a Gq protein-coupled receptor encoded by the AVPR1A gene, primarily distributed in vascular smooth muscle, liver, platelets, and the central nervous system (such as the hippocampus and amygdala).
Its core function, upon activation by arginine vasopressin, involves mediating the phospholipase C signaling pathway via Gq protein to induce vasoconstriction, hepatic glycogenolysis, and platelet aggregation, as well as participating in the regulation of social behavior, mood, and blood pressure homeostasis.
This receptor plays significant roles in conditions such as hypertension, heart failure, and social disorders, serving as a therapeutic target for clinical drugs (e.g., conivaptan).