CHO-K1/Rat OX1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0177C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Orexin Receptor 1 (OXR1), also known as HCRTR1, is a G protein-coupled receptor (GPCR) primarily expressed in the hypothalamic region. By binding to its endogenous ligand orexin-A, it activates intracellular signaling cascades mediated by Gq proteins. Its core functions include regulating energy metabolism balance, stress responses, and the sleep-wake cycle. Dysregulation of OX1R is associated with insomnia, narcolepsy, and obesity.
Screeningbio’s CHO-K1/Rat OX1 cell line overexpress OX1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | HCRTR1 |
Accession Number | SNB-G-0177C |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Orexin Receptor 1 (OXR1), also known as HCRTR1, is a G protein-coupled receptor (GPCR) primarily expressed in the hypothalamic region.
By binding to its endogenous ligand orexin-A, it activates intracellular signaling cascades mediated by Gq proteins. Its core functions include regulating energy metabolism balance, stress responses, and the sleep-wake cycle. Dysregulation of OX1R is associated with insomnia, narcolepsy, and obesity.