CHO-K1/Rat NTS1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0171C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The neurotensin receptor 1 (NTS1) is a high-affinity G protein-coupled receptor for neurotensin. It is primarily distributed in the central nervous system (e.g., substantia nigra, ventral tegmental area, hypothalamus, and amygdala) and the gastrointestinal tract (e.g., enteroendocrine cells and myenteric neurons). Its core function, mediated via Gq protein signaling, involves regulating dopaminergic neurotransmission, appetite suppression, visceral pain perception, as well as intestinal secretion and motility. It is closely associated with the pathophysiology of conditions such as schizophrenia, addiction, obesity, and certain gastrointestinal cancers.
Screeningbio’s CHO-K1/Rat NTS1 cell line overexpress NTSR1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | NTSR1 |
Accession Number | SNB-G-0171C |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The neurotensin receptor 1 (NTS1) is a high-affinity G protein-coupled receptor for neurotensin. It is primarily distributed in the central nervous system (e.g., substantia nigra, ventral tegmental area, hypothalamus, and amygdala) and the gastrointestinal tract (e.g., enteroendocrine cells and myenteric neurons).
Its core function, mediated via Gq protein signaling, involves regulating dopaminergic neurotransmission, appetite suppression, visceral pain perception, as well as intestinal secretion and motility. It is closely associated with the pathophysiology of conditions such as schizophrenia, addiction, obesity, and certain gastrointestinal cancers.