CHO-K1/Rat NK2R Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0219C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Tachykinin receptors are a family of G protein-coupled receptors (GPCRs) comprising three distinct subtypes: neurokinin 1 (NK1), NK2, and NK3 receptors, each exhibiting unique ligand specificity, tissue distribution, and functional roles. These receptors are activated by structurally related neuropeptides—substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)—which share a conserved C-terminal sequence (-Phe-X-Gly-Leu-Met-NH₂).
Screeningbio’s CHO-K1/Rat NK2R cell line overexpress TACR2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | NK2R |
Accession Number | NM_080768 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Tachykinin receptors are a family of G protein-coupled receptors (GPCRs) comprising three distinct subtypes: neurokinin 1 (NK1), NK2, and NK3 receptors, each exhibiting unique ligand specificity, tissue distribution, and functional roles.
These receptors are activated by structurally related neuropeptides—substance P (SP), neurokinin A (NKA), and neurokinin B (NKB)—which share a conserved C-terminal sequence (-Phe-X-Gly-Leu-Met-NH₂).