CHO-K1/Rat IP Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0201C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The IP receptor (prostacyclin receptor) is a G protein-coupled receptor activated by PGI2 (prostacyclin), primarily coupling to the Gs protein. It is widely distributed on vascular endothelial and smooth muscle cells, platelets, kidneys (glomeruli), heart, and certain immune cells. Its core function involves elevating intracellular cAMP levels upon activation, thereby mediating potent vasodilation, inhibiting platelet aggregation, protecting the vascular endothelium, regulating renal blood flow, and contributing to anti-inflammatory and anti-proliferative effects. This receptor is an important therapeutic target for pulmonary arterial hypertension (e.g., using iloprost, treprostinil) and thrombosis prevention.
Screeningbio’s CHO-K1/Rat IP cell line overexpress PTGIR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | PTGIR |
Accession Number | NM_001077644 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The IP receptor (prostacyclin receptor) is a G protein-coupled receptor activated by PGI2 (prostacyclin), primarily coupling to the Gs protein.
It is widely distributed on vascular endothelial and smooth muscle cells, platelets, kidneys (glomeruli), heart, and certain immune cells. Its core function involves elevating intracellular cAMP levels upon activation, thereby mediating potent vasodilation, inhibiting platelet aggregation, protecting the vascular endothelium, regulating renal blood flow, and contributing to anti-inflammatory and anti-proliferative effects.
This receptor is an important therapeutic target for pulmonary arterial hypertension (e.g., using iloprost, treprostinil) and thrombosis prevention.