CHO-K1/Rat GLP-1 β-Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0106G | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Glucagon-Like Peptide-1 Receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) that plays a central role in glucose metabolism by mediating the effects of the incretin hormone GLP-1. GLP-1R is primarily expressed in pancreatic β-cells, as well as in the gastrointestinal tract and central nervous system. Activation of GLP-1R enhances glucose-dependent insulin secretion, inhibits glucagon release, delays gastric emptying, and promotes satiety.
ScreeningBio’s Rat GLP-1R β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | GLP-1 |
Accession Number | NM_012728 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Glucagon-Like Peptide-1 Receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) that plays a central role in glucose metabolism by mediating the effects of the incretin hormone GLP-1.
GLP-1R is primarily expressed in pancreatic β-cells, as well as in the gastrointestinal tract and central nervous system. Activation of GLP-1R enhances glucose-dependent insulin secretion, inhibits glucagon release, delays gastric emptying, and promotes satiety.