CHO-K1/Rat FSH Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0108C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor that specifically binds follicle-stimulating hormone. It is primarily distributed in ovarian granulosa cells in females and testicular Sertoli cells in males, with minor expression in non-gonadal tissues such as bone and vascular endothelium. Its core function is to mediate FSH signaling, governing gametogenesis and sex hormone production: in the ovary, it regulates follicular development, estrogen synthesis, and ovulation; in the testis, it promotes spermatogenesis and supports Sertoli cell function. Thus, FSHR is a central regulatory component of the reproductive endocrine system, with dysfunction directly linked to conditions including polycystic ovary syndrome, infertility, and hypogonadism, making it a critical target for assisted reproduction and related therapies.
Screeningbio’s CHO-K1/Rat FSH cell line overexpress Rat FSHR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | FSHR |
Accession Number | NM_199237 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor that specifically binds follicle-stimulating hormone. It is primarily distributed in ovarian granulosa cells in females and testicular Sertoli cells in males, with minor expression in non-gonadal tissues such as bone and vascular endothelium.
Its core function is to mediate FSH signaling, governing gametogenesis and sex hormone production: in the ovary, it regulates follicular development, estrogen synthesis, and ovulation; in the testis, it promotes spermatogenesis and supports Sertoli cell function.
Thus, FSHR is a central regulatory component of the reproductive endocrine system, with dysfunction directly linked to conditions including polycystic ovary syndrome, infertility, and hypogonadism, making it a critical target for assisted reproduction and related therapies.