CHO-K1/Rat DP1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0194C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The DP1 receptor (Prostaglandin D2 receptor 1) is a G protein-coupled receptor encoded by the PTGDR gene, belonging to the prostanoid receptor family. It is primarily distributed in mast cells, eosinophils, airway epithelial cells, vascular endothelial cells, and the central nervous system. Its core function involves binding the endogenous ligand prostaglandin D2 and activating the Gs protein to increase intracellular cAMP levels, thereby playing key roles in sleep induction, allergic response regulation, smooth muscle relaxation, vasodilation, and immune modulation. This receptor is an important therapeutic target for asthma, allergic rhinitis, and inflammatory diseases.
Screeningbio’s CHO-K1/Rat DP1 cell line overexpress Rat PTGDR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | PTGDR |
Accession Number | NM_022241 (Rn) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The DP1 receptor (Prostaglandin D2 receptor 1) is a G protein-coupled receptor encoded by the PTGDR gene, belonging to the prostanoid receptor family.
It is primarily distributed in mast cells, eosinophils, airway epithelial cells, vascular endothelial cells, and the central nervous system. Its core function involves binding the endogenous ligand prostaglandin D2 and activating the Gs protein to increase intracellular cAMP levels, thereby playing key roles in sleep induction, allergic response regulation, smooth muscle relaxation, vasodilation, and immune modulation. This receptor is an important therapeutic target for asthma, allergic rhinitis, and inflammatory diseases.