CHO-K1/Rat CCR6 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0057C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Chemokine (C-C motif) receptor 6 (CCR6) is a G protein-coupled receptor whose sole known chemokine ligand is CCL20. It is primarily expressed on Th17 cells, regulatory T cells, B lymphocytes, and specific subsets of dendritic cells. The "CCL20-CCR6" axis serves as a critical pathway for lymphocyte homing to mucosal sites and inflamed tissues, playing a central role in maintaining gut homeostasis, defending against bacterial infections, and driving autoimmune inflammation (such as in psoriasis, rheumatoid arthritis, and inflammatory bowel disease). Consequently, CCR6 is an important therapeutic target for autoimmune and inflammatory diseases.
Screeningbio’s CHO-K1/Rat CCR6 cell line overexpress CCR6 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CCR6 |
Accession Number | NM_001013145 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Chemokine (C-C motif) receptor 6 (CCR6) is a G protein-coupled receptor whose sole known chemokine ligand is CCL20. It is primarily expressed on Th17 cells, regulatory T cells, B lymphocytes, and specific subsets of dendritic cells. The "CCL20-CCR6" axis serves as a critical pathway for lymphocyte homing to mucosal sites and inflamed tissues, playing a central role in maintaining gut homeostasis, defending against bacterial infections, and driving autoimmune inflammation (such as in psoriasis, rheumatoid arthritis, and inflammatory bowel disease). Consequently, CCR6 is an important therapeutic target for autoimmune and inflammatory diseases.
Screeningbio’s CHO-K1/Rat CCR6 cell line overexpress CCR6 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.