CHO-K1/Rat CCK1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0075C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Cholecystokinin A receptor (CCK1 or CCK-A) is a G protein-coupled receptor primarily responsive to the hormone cholecystokinin. It is predominantly distributed in the gastrointestinal system (e.g., gallbladder, pancreas, sphincter of Oddi, gastric and intestinal smooth muscle) and specific regions of the central nervous system (e.g., nucleus tractus solitarius). Its main function is to mediate the physiological actions of cholecystokinin, including stimulating gallbladder contraction and bile release, promoting pancreatic enzyme secretion, regulating gastric emptying and intestinal motility, and participating in the central regulation of behaviors such as satiety and anxiety. Consequently, CCK1 is a significant therapeutic target for modulating digestive functions and treating related disorders such as functional gastrointestinal disorders and obesity.
Screeningbio’s CHO-K1/Rat CCK1 cell line overexpress CCK1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CCK1 |
Accession Number | NM_012688 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Cholecystokinin A receptor (CCK1 or CCK-A) is a G protein-coupled receptor primarily responsive to the hormone cholecystokinin. It is predominantly distributed in the gastrointestinal system (e.g., gallbladder, pancreas, sphincter of Oddi, gastric and intestinal smooth muscle) and specific regions of the central nervous system (e.g., nucleus tractus solitarius).
Its main function is to mediate the physiological actions of cholecystokinin, including stimulating gallbladder contraction and bile release, promoting pancreatic enzyme secretion, regulating gastric emptying and intestinal motility, and participating in the central regulation of behaviors such as satiety and anxiety. Consequently, CCK1 is a significant therapeutic target for modulating digestive functions and treating related disorders such as functional gastrointestinal disorders and obesity.