CHO-K1/Rat CB1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0048C | $19,800 |
Membrane Preparation | SNB-GM-0048C | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The Cannabinoid receptor 1 is a primary G protein-coupled receptor of the endocannabinoid system. It is highly concentrated in the central nervous system, particularly in the basal ganglia, cerebellum, hippocampus, and cortex of the brain, with some expression also found in the peripheral nervous system and organs like adipose tissue, liver, and muscle. Its primary function is to modulate neurotransmitter release, thereby participating in the regulation of various physiological processes, including memory and learning, mood, appetite, pain perception, and motor coordination. Consequently, it is the main target of tetrahydrocannabinol and an important target for developing therapeutics such as analgesics and antiemetics.
Screeningbio’s CHO-K1/Rat CB1 cell line overexpress CNR1 and is designed to detect decreases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | CB1 |
Accession Number | NM_012784 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The Cannabinoid receptor 1 is a primary G protein-coupled receptor of the endocannabinoid system. It is highly concentrated in the central nervous system, particularly in the basal ganglia, cerebellum, hippocampus, and cortex of the brain, with some expression also found in the peripheral nervous system and organs like adipose tissue, liver, and muscle.
Its primary function is to modulate neurotransmitter release, thereby participating in the regulation of various physiological processes, including memory and learning, mood, appetite, pain perception, and motor coordination. Consequently, it is the main target of tetrahydrocannabinol and an important target for developing therapeutics such as analgesics and antiemetics.