CHO-K1/Rat B2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0039C | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The bradykinin B2 receptor is a widely and constitutively expressed G protein-coupled receptor that serves as the primary mediator for the kinin system. It is ubiquitously present on vascular endothelial cells, smooth muscle cells, and neurons. Its key functions include mediating acute vasodilation (leading to hypotension), increasing vascular permeability (causing edema), and eliciting pain and cough reflexes. It also plays a critical role in the pathophysiology of shock.
Screeningbio’s CHO-K1/Rat B2 Gq cell line overexpress BDKRB2 and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Rat |
HGNC Symbol | B2 |
Accession Number | NM_173100 |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The bradykinin B2 receptor is a widely and constitutively expressed G protein-coupled receptor that serves as the primary mediator for the kinin system. It is ubiquitously present on vascular endothelial cells, smooth muscle cells, and neurons. Its key functions include mediating acute vasodilation (leading to hypotension), increasing vascular permeability (causing edema), and eliciting pain and cough reflexes. It also plays a critical role in the pathophysiology of shock.