Product Description

The VPAC2 receptor (vasoactive intestinal peptide receptor 2) is a class B G protein-coupled receptor encoded by the VIPR2 gene, binding to both vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. It is primarily distributed in vascular smooth muscle, gastrointestinal tract, lungs, pancreatic β-cells, heart, brain (particularly the suprachiasmatic nucleus), and immune cells such as T cells. Its core function involves activating Gs proteins to stimulate cAMP production, thereby mediating vasodilation, bronchial and gastrointestinal smooth muscle relaxation, promoting insulin secretion, regulating circadian rhythms, and suppressing immune cell activity (e.g., T cell proliferation). This receptor holds significant therapeutic potential in treating type 2 diabetes (enhancing insulin release), asthma (bronchodilation), and immunomodulation.

Screeningbio’s CHO-K1/Mouse VPAC2 cell line overexpress VIPR2 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.