Product Description

The Nociceptin/Orphanin FQ Peptide Receptor (NOP) is the fourth member of the opioid receptor family, a G protein-coupled receptor that binds its endogenous ligand, nociceptin/orphanin FQ, rather than classic opioid peptides. It is widely expressed throughout the central nervous system (e.g., cerebral cortex, amygdala, hippocampus, spinal cord) and some peripheral tissues. The NOP receptor has complex functions, modulating pain perception (its effects can be bidirectional, producing both analgesia and hyperalgesia), mood and stress responses, learning and memory, reward behaviors, as well as food intake and locomotor activity. Unlike classic mu receptor agonists, NOP agonists do not produce typical opioid-like respiratory depression or high addictive potential, making the NOP receptor a promising target for developing novel non-addictive analgesics and anxiolytic/antidepressant drugs.

Screeningbio’s CHO-K1/Mouse NOP cell line overexpress OPRL1 and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.