CHO-K1/Mouse MT1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0147B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
MT1 (Melatonin Receptor 1A, MTNR1A) is one of the two primary high-affinity G protein-coupled receptors for melatonin. It is predominantly distributed in the suprachiasmatic nucleus of the brain, retina, pituitary gland, and gonadal tissues. Its core function is to mediate the rhythmic signals of melatonin, acting as a critical "circadian coordinator." By inhibiting cAMP production via Gi/o protein signaling, it regulates circadian rhythms, sleep-wake cycles, and participates in seasonal reproduction, thermoregulation, and immune function modulation. The diurnal fluctuation of its expression and activity forms the molecular foundation linking environmental light-dark cycles to intrinsic physiological functions.
Screeningbio’s CHO-K1/Mouse MT1 cell line overexpress mouse MTNR1A and is designed to detect inhibition in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | MTNR1A |
Accession Number | SNB-G-0147B |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
MT1 (Melatonin Receptor 1A, MTNR1A) is one of the two primary high-affinity G protein-coupled receptors for melatonin. It is predominantly distributed in the suprachiasmatic nucleus of the brain, retina, pituitary gland, and gonadal tissues. Its core function is to mediate the rhythmic signals of melatonin, acting as a critical "circadian coordinator."
By inhibiting cAMP production via Gi/o protein signaling, it regulates circadian rhythms, sleep-wake cycles, and participates in seasonal reproduction, thermoregulation, and immune function modulation.
The diurnal fluctuation of its expression and activity forms the molecular foundation linking environmental light-dark cycles to intrinsic physiological functions.