CHO-K1/Mouse M5 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0017B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The M5 muscarinic acetylcholine receptor (CHRM5) is a member of the muscarinic acetylcholine receptor (mAChRs) family and belongs to the class of G protein-coupled receptors. It is primarily distributed in the central nervous system (such as midbrain dopaminergic neurons and the striatum) as well as in peripheral tissues (e.g., pancreatic β-cells). By modulating acetylcholine signaling, it contributes to the regulation of reward pathways, metabolic homeostasis, and drug addiction behaviors.
Screeningbio’s CHO-K1/Mouse M5 Gq cell line overexpress CHRM5 receptor and is designed to detect increases in intracellular Calcium flux signal in response to agonist stimulation of the receptor. Molecular Devices Calcium 6 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | CHRM5 |
Accession Number | NM_205783 (Mm) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The M5 muscarinic acetylcholine receptor (CHRM5) is a member of the muscarinic acetylcholine receptor (mAChRs) family and belongs to the class of G protein-coupled receptors.
It is primarily distributed in the central nervous system (such as midbrain dopaminergic neurons and the striatum) as well as in peripheral tissues (e.g., pancreatic β-cells). By modulating acetylcholine signaling, it contributes to the regulation of reward pathways, metabolic homeostasis, and drug addiction behaviors.