Product Description

CRF1 receptor (CRHR1), a G protein-coupled receptor, is the primary receptor for corticotropin-releasing hormone. It is widely distributed in brain regions involved in stress and emotional regulation, such as the amygdala, hypothalamus, and cerebral cortex, and also expressed in the anterior pituitary and immune system. As the "master switch" of the body's stress response, its activation initiates the hypothalamic-pituitary-adrenal axis, leading to cortisol release. It directly regulates behaviors like anxiety, depression, learning, and memory. Consequently, CRF1 receptor antagonists represent a major research direction for developing novel therapies for depression, anxiety, and other stress-related psychiatric disorders.

Screeningbio’s CHO-K1/Mouse CRF1 cell line overexpress CRHR1 and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.