CHO-K1/Human TRH1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0221A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The TRH1 receptor (thyrotropin-releasing hormone receptor 1) is a Gq/11 protein-coupled receptor that specifically binds thyrotropin-releasing hormone. It is primarily distributed in the anterior pituitary gland and the central nervous system (such as the cerebral cortex, hippocampus, and amygdala), and is also expressed in peripheral tissues including the retina and pancreas. Its core function, upon activation by TRH, involves stimulating phospholipase C via Gq/11 proteins to generate IP3 and DAG, thereby mobilizing intracellular calcium. In the pituitary, it primarily stimulates the release of thyroid-stimulating hormone and prolactin to regulate thyroid axis function, while in the central nervous system, it acts as a neuromodulator involved in regulating depression and anxiety behaviors, cognition, and pain perception.
Screeningbio’s CHO-K1/Human TRH1 cell line overexpress TRHR receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | TRHR |
Accession Number | NM_003301 (Hs) |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The TRH1 receptor (thyrotropin-releasing hormone receptor 1) is a Gq/11 protein-coupled receptor that specifically binds thyrotropin-releasing hormone.
It is primarily distributed in the anterior pituitary gland and the central nervous system (such as the cerebral cortex, hippocampus, and amygdala), and is also expressed in peripheral tissues including the retina and pancreas. Its core function, upon activation by TRH, involves stimulating phospholipase C via Gq/11 proteins to generate IP3 and DAG, thereby mobilizing intracellular calcium.
In the pituitary, it primarily stimulates the release of thyroid-stimulating hormone and prolactin to regulate thyroid axis function, while in the central nervous system, it acts as a neuromodulator involved in regulating depression and anxiety behaviors, cognition, and pain perception.