CHO-K1/Human P2Y6 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0183A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The pyrimidinergic receptor P2Y6 is a Gq protein-coupled receptor primarily activated by UDP, belonging to the purinergic P2Y receptor family. It is widely expressed in various tissues including the spleen, placenta, intestines, blood vessels, skeletal muscle, heart, and immune cells such as macrophages. Its core function is to serve as a regulatory hub for inflammation and tissue homeostasis: in immune cells, it mediates the release of inflammatory cytokines, driving inflammatory responses; in the vascular system, it regulates endothelial function and smooth muscle contraction; meanwhile, in the nervous system, it promotes microglial phagocytosis and, under specific conditions, exerts anti-apoptotic effects, protecting the heart and skeletal muscle. Consequently, the P2Y6 receptor is closely associated with various pathological processes such as atherosclerosis, ischemia-reperfusion injury, and neuroinflammation.
Screeningbio’s CHO-K1/Human P2Y6 cell line overexpress P2RY6 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | P2RY6 |
Accession Number | SNB-G-0183A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The pyrimidinergic receptor P2Y6 is a Gq protein-coupled receptor primarily activated by UDP, belonging to the purinergic P2Y receptor family. It is widely expressed in various tissues including the spleen, placenta, intestines, blood vessels, skeletal muscle, heart, and immune cells such as macrophages.
Its core function is to serve as a regulatory hub for inflammation and tissue homeostasis: in immune cells, it mediates the release of inflammatory cytokines, driving inflammatory responses; in the vascular system, it regulates endothelial function and smooth muscle contraction; meanwhile, in the nervous system, it promotes microglial phagocytosis and, under specific conditions, exerts anti-apoptotic effects, protecting the heart and skeletal muscle.
Consequently, the P2Y6 receptor is closely associated with various pathological processes such as atherosclerosis, ischemia-reperfusion injury, and neuroinflammation.