CHO-K1/Human NPS Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0163A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Neuropeptide S receptor 1 (NPS receptor) is a G protein-coupled receptor widely distributed within the central nervous system, primarily in brain regions associated with arousal, anxiety, stress, and reward regulation, such as the locus coeruleus, amygdala, and hypothalamus. Its main function, upon binding to its endogenous ligand neuropeptide S, is to significantly promote wakefulness, reduce anxiety-related behaviors, modulate stress responses, and participate in learning, memory processes, as well as the regulation of addiction-related behaviors. This receptor is considered the key mediator for the core effects of neuropeptide S in promoting arousal and exerting anxiolytic actions.
Screeningbio’s CHO-K1/Human NPS cell line overexpress NPSR1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | NPS receptor |
Accession Number | SNB-G-0163A |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Neuropeptide S receptor 1 (NPS receptor) is a G protein-coupled receptor widely distributed within the central nervous system, primarily in brain regions associated with arousal, anxiety, stress, and reward regulation, such as the locus coeruleus, amygdala, and hypothalamus.
Its main function, upon binding to its endogenous ligand neuropeptide S, is to significantly promote wakefulness, reduce anxiety-related behaviors, modulate stress responses, and participate in learning, memory processes, as well as the regulation of addiction-related behaviors. This receptor is considered the key mediator for the core effects of neuropeptide S in promoting arousal and exerting anxiolytic actions.