Product Description

The growth hormone-releasing hormone receptor (GHRHR) is a G protein-coupled receptor that specifically binds to growth hormone-releasing hormone (GHRH) secreted by the hypothalamus. It is primarily located on growth hormone-secreting cells (somatotrophs) in the anterior pituitary, with additional expression in the hypothalamus, pancreas, immune cells, and various peripheral tissues and tumors. Its core function is to potently stimulate the synthesis and pulsatile secretion of growth hormone (GH) by activating the Gαs-cAMP-PKA signaling pathway, thereby governing body linear growth, metabolism, and cellular repair. As a central component of the hypothalamic-pituitary growth axis, its overactivity is linked to acromegaly, while its deficiency leads to growth hormone deficiency, making it a critical target for the diagnosis and treatment of related endocrine disorders (e.g., GHRH analogs).

Screeningbio’s CHO-K1/Human GHRH cell line overexpress GHRHR receptor and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.