Product Description

AMY3 (CTR-RAMP3) is a subtype of the amylin receptor, a heterodimeric G protein-coupled receptor complex composed of the calcitonin receptor and receptor activity-modifying protein 3. Compared to AMY1, AMY3 has a broader distribution in peripheral tissues, with notable expression in the lungs, vascular smooth muscle, skeletal muscle, and some tumor tissues. It can bind not only to amylin (with relatively lower affinity) but also effectively to adrenomedullin and CGRP, endowing it with more diverse functions. Its primary roles may involve regulating peripheral vascular tone and lung function, and under specific conditions, participating in metabolic regulation and modulating the tumor microenvironment. Thus, AMY3 is not only a potential target for metabolic diseases like diabetes but may also be implicated in the pathophysiology of cardiovascular diseases and cancer.

Screeningbio’s CHO-K1/Human CTR-RAMP3 (AMY3) cell line overexpress both CT receptor and RAMP3 accessory protein (also named AMY3). The cell line is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.