CHO-K1 SRF-RE-Luciferase Reporter Cell Line
Item | Cat# | Price |
Stable Cell Line | SNB-SP-0018 | $1,980 |
Compound Test Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The SRF-RE pathway centers on transcription factor SRF. It is primarily activated via two routes: ① Growth factors activate the Ras-MAPK pathway, phosphorylating the cofactor TCF, which then binds SRF to initiate proliferation genes; ② Cytoskeletal changes activate the RhoA pathway, mobilizing the cofactor MRTF to bind SRF and drive genes for motility and morphology. This pathway integrates signals to coordinately regulate cell proliferation, differentiation, and morphological remodeling.
Screeningbio’s CHO-K1/SRF-RE/Luciferase reporter gene cell line stable transfected with SRF-RE response element and luciferase gene. Upon stimulated, SRF-RE pathway was activated and induce luciferase expression.
Product Specifications
Target Type | Signal Pathway |
Species | Human |
HGNC Symbol | |
Accession Number | |
Parental Line | CHO-K1 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The SRF-RE pathway centers on transcription factor SRF. It is primarily activated via two routes: ① Growth factors activate the Ras-MAPK pathway, phosphorylating the cofactor TCF, which then binds SRF to initiate proliferation genes; ② Cytoskeletal changes activate the RhoA pathway, mobilizing the cofactor MRTF to bind SRF and drive genes for motility and morphology. This pathway integrates signals to coordinately regulate cell proliferation, differentiation, and morphological remodeling.