HEK293 Human NPR1 Cell Line

HEK293/Human NPR1 Cell Line

Item	Cat#	Price
Stable Cell Line	SNB-OT-0007	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

Natriuretic Peptide Receptor 1 (NPR1) is a critical receptor for cardiovascular regulation. It is the essential gateway for the heart's hormones (ANP/BNP) to lower blood pressure by driving cGMP production. NPR1 is genetically essential for survival, clinically validated as a life-saving drug target, and physiologically central as the heart's primary self-defense mechanism. Its integrity is fundamental to cardiovascular health, and its modulation represents a cornerstone of advanced cardiovascular therapeutics.

Screeningbio’s HEK293/Human NPR1 cell line overexpress NPR1 and is designed to detect increases in intracellular cGMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cGMP kit can be used to detect the signal.

Product Specifications

Target Type	Catalytic receptors
Species	Cyno
HGNC Symbol	NPR1
Accession Number
Parental Line	HEK293
Lot#	See Vial
Storage	Liquid Nitrogen

Data

HEK293/NPR1 Agonist Assay. HEK293/NPR1 cells were treated with reference agonist REGN5381. The assay was run based on Revvity cGMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software. — **HEK293/NPR1 Agonist Assay.** HEK293/NPR1 cells were treated with reference agonist REGN5381. The assay was run based on Revvity cGMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.

Target Background

Natriuretic Peptide Receptor 1 (NPR1) is a critical receptor for cardiovascular regulation. It is the essential gateway for the heart's hormones (ANP/BNP) to lower blood pressure by driving cGMP production. NPR1 is genetically essential for survival, clinically validated as a life-saving drug target, and physiologically central as the heart's primary self-defense mechanism. Its integrity is fundamental to cardiovascular health, and its modulation represents a cornerstone of advanced cardiovascular therapeutics.