HEK293T Human β2-adrenoceptor β Arrestin Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-A-0029A | Inquiry |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
The β2-adrenoceptor (β2-AR) is an important member of the G protein-coupled receptor family and plays a broad role in regulating physiological processes such as cardiovascular function, respiratory control, and metabolic processes. This receptor is crucial in modulating airway smooth muscle tone, and its dysregulation is closely associated with the development and progression of various diseases, including nocturnal asthma, obesity, type 2 diabetes, and cardiovascular diseases. Due to its significant physiological functions, current drug development targeting the β2 receptor primarily focuses on creating novel agonists and antagonists, offering new therapeutic strategies for respiratory diseases, tumors, and other disorders.
ScreeningBio’s HEK293T/Human β2-adrenoceptor β-Arrestin cell line co-express the SmBiT tagged β2-adrenoceptor and the LgBiT tagged β-Arrestin. Activation of the GPCR-SmBiT induces β-Arrestin-LgBiT recruitment, forcing complementation of two NanoBiT enzyme fragments (SmBiT and LgBiT). The resulting functional NanoBiT enzyme catalyze substrate to generate a luminescent signal. Promega Nano-Glo Live Cell Kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | ADRB2 |
Accession Number | NM_000024 (Hs) |
Parental Line | HEK293T |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
The β2-adrenoceptor (β2-AR) is an important member of the G protein-coupled receptor family and plays a broad role in regulating physiological processes such as cardiovascular function, respiratory control, and metabolic processes. This receptor is crucial in modulating airway smooth muscle tone, and its dysregulation is closely associated with the development and progression of various diseases, including nocturnal asthma, obesity, type 2 diabetes, and cardiovascular diseases.
Due to its significant physiological functions, current drug development targeting the β2 receptor primarily focuses on creating novel agonists and antagonists, offering new therapeutic strategies for respiratory diseases, tumors, and other disorders.