Product Description

The SST2 receptor (somatostatin receptor 2) is a high-affinity G protein-coupled receptor for somatostatin and represents the most widely distributed functional subtype within the somatostatin receptor family. It is primarily distributed in the central nervous system, pituitary gland, pancreas (α and β cells), adrenal glands, as well as in gastrointestinal lymphoid tissue and nerve plexuses, and is significantly overexpressed in most neuroendocrine tumors. Its core function involves inhibiting adenylyl cyclase via Gi/o proteins and modulating calcium channels, thereby potently suppressing the secretion of various hormones while regulating neurotransmitter release, inhibiting cell proliferation, and inducing apoptosis. This receptor serves as a critical molecular target for the clinical diagnosis and treatment of neuroendocrine tumors.

ScreeningBio’s HEK293T/Human SST2 β-arrestin cell line is an ideal tool for studying GPCR/β-arrestin interactions. In this system, the GPCR C-terminus is fused to a smallBiT tag, and the β2-arrestin N-terminus is fused to a largeBiT tag. Upon receptor activation, GPCR/β-arrestin interaction brings the two fragments together to reconstitute an active NanoLuc enzyme, which can be quantified using the NanoBiT substrate. This cell line is designed to evaluate a compound’s ability to activate the β-arrestin signaling pathway.