HEK293/Mouse MRGPRX2 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0270B | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
MRGPRX2 (Mas-related G protein-coupled receptor member X2) is a G protein-coupled receptor (GPCR) primarily expressed in mast cells and certain neural tissues. It is involved in various physiological and pathological processes, including pain sensation, immune responses, and inflammation. The neuro-immune hyperactivation mediated by MRGPRX2 is a common feature of many chronic diseases, such as allergy, autoimmunity, pain, and pruritus.
Screeningbio’s HEK293/Mouse MRGPRX2 cell line overexpress MRGPRX2 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Mouse |
HGNC Symbol | MRGPRX2 |
Accession Number | NM_001034868.3 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
![HEK293/Mouse MRGPRX2 Agonist Assay. HEK293/Mouse MRGPRX2 cells were treated with the reference agonist Substance P and Hemokinin 1 (human) acetate. The assay was run based on Revvity IP-one HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 /IC50 values were determined, using GraphPad Prism software.](https://static.wixstatic.com/media/cbf7de_31675b35ffe14a6bab549dbc5ef7a5e1~mv2.png/v1/fill/w_75,h_75,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/cbf7de_31675b35ffe14a6bab549dbc5ef7a5e1~mv2.png)
Target Background
MRGPRX2 (Mas-related G protein-coupled receptor member X2) is a G protein-coupled receptor (GPCR) primarily expressed in mast cells and certain neural tissues. It is involved in various physiological and pathological processes, including pain sensation, immune responses, and inflammation. The neuro-immune hyperactivation mediated by MRGPRX2 is a common feature of many chronic diseases, such as allergy, autoimmunity, pain, and pruritus.