HEK293/Human GPR55 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0113A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
G protein-coupled receptor 55 (GPR55) is an orphan receptor activated by various lipid ligands, including lysophosphatidylinositol and certain cannabinoids. It is widely distributed in the central nervous system (e.g., cerebellum, hippocampus), immune cells (especially the spleen), bone, gastrointestinal tract, and vascular endothelium. Its core function is to serve as a multifunctional integrator of metabolism and signaling. Upon activation, it couples to proteins such as Gα13 and Gαq/11, participating in the regulation of diverse physiological processes including bone remodeling, neuroinflammation, pain perception, insulin secretion, and intestinal motility. Abnormal activation of GPR55 is closely linked to osteoporosis, neurodegenerative diseases, inflammatory bowel disease, and cancer progression, making it a novel potential therapeutic target for metabolic and immune-related disorders.
Screeningbio’s HEK293/Human GPR55 cell line overexpress GPR55 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | GPR55 |
Accession Number | NM_005683 (Hs) |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
G protein-coupled receptor 55 (GPR55) is an orphan receptor activated by various lipid ligands, including lysophosphatidylinositol and certain cannabinoids. It is widely distributed in the central nervous system (e.g., cerebellum, hippocampus), immune cells (especially the spleen), bone, gastrointestinal tract, and vascular endothelium.
Its core function is to serve as a multifunctional integrator of metabolism and signaling. Upon activation, it couples to proteins such as Gα13 and Gαq/11, participating in the regulation of diverse physiological processes including bone remodeling, neuroinflammation, pain perception, insulin secretion, and intestinal motility.
Abnormal activation of GPR55 is closely linked to osteoporosis, neurodegenerative diseases, inflammatory bowel disease, and cancer progression, making it a novel potential therapeutic target for metabolic and immune-related disorders.