HEK293 Human FSH Stable Cell

HEK293/Human FSH Stable Cell

Item	Cat#	Price
Stable Cell Line	SNB-G-0108D	$19,800
Compound Testing Services	CT-001	$1,850 per 384w plate *(Up To 16 cpds Dose)*

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Product Description

The follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor that specifically binds follicle-stimulating hormone. It is primarily distributed in ovarian granulosa cells in females and testicular Sertoli cells in males, with minor expression in non-gonadal tissues such as bone and vascular endothelium. Its core function is to mediate FSH signaling, governing gametogenesis and sex hormone production: in the ovary, it regulates follicular development, estrogen synthesis, and ovulation; in the testis, it promotes spermatogenesis and supports Sertoli cell function. Thus, FSHR is a central regulatory component of the reproductive endocrine system, with dysfunction directly linked to conditions including polycystic ovary syndrome, infertility, and hypogonadism, making it a critical target for assisted reproduction and related therapies.

Screeningbio’s HEK293/Human FSH cell line overexpress FSHR and is designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. Cisbio HTRF cAMP kit can be used to detect the signal.

Product Specifications

Target Type	GPCR
Species	Human
HGNC Symbol	FSHR
Accession Number	NM_000145 (Hs)
Parental Line	HEK293
Lot#	See Vial
Storage	Liquid Nitrogen

Data

HEK293/Human FSH Agonist Assay. HEK293/Human FSH cells were treated with the reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software. — **HEK293/Human FSH Agonist Assay.** HEK293/Human FSH cells were treated with the reference agonist. The assay was run based on Revvity cAMP HTRF protocol. Non-linear regression was used to plot activity changes vs. [Compound, M], and EC50 values were determined, using GraphPad Prism software.

Target Background

The follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor that specifically binds follicle-stimulating hormone. It is primarily distributed in ovarian granulosa cells in females and testicular Sertoli cells in males, with minor expression in non-gonadal tissues such as bone and vascular endothelium.

Its core function is to mediate FSH signaling, governing gametogenesis and sex hormone production: in the ovary, it regulates follicular development, estrogen synthesis, and ovulation; in the testis, it promotes spermatogenesis and supports Sertoli cell function.

Thus, FSHR is a central regulatory component of the reproductive endocrine system, with dysfunction directly linked to conditions including polycystic ovary syndrome, infertility, and hypogonadism, making it a critical target for assisted reproduction and related therapies.