HEK293/Human FFA4 (GPR120) Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0096A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
Free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor sensitive to long-chain unsaturated fatty acids, particularly omega-3 fatty acids. It is widely expressed in intestinal enteroendocrine cells, adipose tissue, macrophages, and the liver. Its core function is to serve as a critical integrator of metabolism and inflammation: in the gut, it mediates GLP-1 secretion to regulate blood sugar and appetite; in adipose tissue and the liver, it promotes insulin sensitization and improves metabolic homeostasis; in macrophages, it exerts potent anti-inflammatory effects by suppressing inflammatory pathways. Consequently, FFA4 is a key molecule linking nutritional signals, metabolic regulation, and chronic inflammation, making it a promising therapeutic target for metabolic-inflammatory diseases such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.
Screeningbio’s HEK293/Human FFA4 (GPR120) cell line overexpress FFA4 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | FFAR4 |
Accession Number | NM_181745 |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
Free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor sensitive to long-chain unsaturated fatty acids, particularly omega-3 fatty acids. It is widely expressed in intestinal enteroendocrine cells, adipose tissue, macrophages, and the liver.
Its core function is to serve as a critical integrator of metabolism and inflammation: in the gut, it mediates GLP-1 secretion to regulate blood sugar and appetite; in adipose tissue and the liver, it promotes insulin sensitization and improves metabolic homeostasis; in macrophages, it exerts potent anti-inflammatory effects by suppressing inflammatory pathways.
Consequently, FFA4 is a key molecule linking nutritional signals, metabolic regulation, and chronic inflammation, making it a promising therapeutic target for metabolic-inflammatory diseases such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.