HEK293/Human EP1 Stable Cell
Item | Cat# | Price |
Stable Cell Line | SNB-G-0196A | $19,800 |
Compound Testing Services | CT-001 | $1,850 per 384w plate (Up To 16 cpds Dose) |
Product Description
EP1, officially known as PTGER1, is one of the four G protein-coupled receptors for prostaglandin E2 (PGE2). It is primarily distributed in the kidneys, lungs, gastrointestinal smooth muscle, as well as the central nervous system and sensory neurons. Functionally, upon activation, the EP1 receptor primarily acts by increasing intracellular calcium ion concentration. It is involved in pain perception (particularly inflammatory pain), febrile response, smooth muscle contraction, and regulating renal water and salt excretion. Consequently, the EP1 receptor is considered a potential drug target for treating inflammatory pain and cardiovascular diseases.
Screeningbio’s HEK293/Human EP1 cell line overexpress PTGER1 receptor and is designed to detect increases in intracellular IP-1 levels in response to agonist stimulation of the receptor. Cisbio HTRF IP-1 kit can be used to detect the signal.
Product Specifications
Target Type | GPCR |
Species | Human |
HGNC Symbol | EP1 |
Accession Number | NM_000955 (Hs) |
Parental Line | HEK293 |
Lot# | See Vial |
Storage | Liquid Nitrogen |
Data
Target Background
EP1, officially known as PTGER1, is one of the four G protein-coupled receptors for prostaglandin E2 (PGE2). It is primarily distributed in the kidneys, lungs, gastrointestinal smooth muscle, as well as the central nervous system and sensory neurons. Functionally, upon activation, the EP1 receptor primarily acts by increasing intracellular calcium ion concentration.
It is involved in pain perception (particularly inflammatory pain), febrile response, smooth muscle contraction, and regulating renal water and salt excretion. Consequently, the EP1 receptor is considered a potential drug target for treating inflammatory pain and cardiovascular diseases.